Histological study of effect of cadmium toxicity on ovarian tissue

Abdel-Aziz Helmya, Dalia Hussien; Embabyb, Azza Saleh; El-saeed, Amany Mohammed

doi:10.21608/ejctr.2023.194004.1001

Histological study of effect of cadmium toxicity on ovarian tissue

Document Type : Original articles

Authors

Histology department, Faculty of Medicine, Beni-Suef University, Egypt

10.21608/ejctr.2023.194004.1001

Abstract

Cadmium is a widespread and dangerous material that leads to different harmful cellular changes up to death. The goal of this study is to detect cadmium damaging effect on ovaries of adult female albino rat . A total of 14 adult female albino rats were divided into two groups, each group was consisted of 7 rats . The control group ( group I) was given only saline orally and the cadmium-treated group (group II) was given CdCl2 dissolved in saline at a dose of 5 mg/kg for 28days. The animals of two groups were sacrificed at the same time and their right ovaries were rapidly dissected out. The specimens of each group were processed for light microscopic examination. They were stained with hematoxylin and eosin and masson's trichrome stains for evaluating histopathological changes in ovarian structure. Quantitative morphometric, and statistical studies were performed. Histological changes in cadmium- treated group were in the form of irregular outline of the ovary with flat squamous germinal epithelium , massive loss of follicles and many atretic follicles with markedly dilated and congested cortical blood vessels. Masson's trichrome stained sections showed marked deposition of collagen fiber in the cortical stroma.

Keywords

Main Subjects

• Histology

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